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Lesions appear rapidly, primarily in an acral distribution in areas of otherwise normal-appearing skin, and range from a few centimeters to very large. Derighetti M, Hohl D, Krayenbuhl B.H, Panizzon R.G. Bullosis diabeticorum in a newly discovered type diabetes mellitus. Dermatology 2000; 200: 366-7. Fung M.A, Murphy M.J, Hoss DM, Berke A, Grant-Kels J.M. The sensivity and specificity of “caterpillar bodies” in the differential diagnosis of subepidermal blistering disorders.
Displays self-limiting course. 2019-12-06 · Bullous disease of diabetes (bullosis diabeticorum) is a distinct, spontaneous, noninflammatory, blistering condition of acral skin that is unique to patients with diabetes mellitus. Kramer first Se hela listan på wikem.org Bullosis diabeticorum: a case report. Monfrecola G, Martellotta D, Bruno G, Delfino M, Iandoli R. PMID: 6393676 [PubMed - indexed for MEDLINE] Publication Types: Case Reports; MeSH Terms. Aged; Diabetes Mellitus, Type 1/pathology* Diagnosis, Differential; Humans; Male; Skin Diseases, Vesiculobullous/diagnosis; Skin Diseases, Vesiculobullous/etiology 2020-08-22 · Bullosis diabeticorum (BD), also known as diabetic bullae or bullous eruption of diabetes mellitus, is a specific type of skin lesion occurring in patients with diabetes mellitus. Kramer first reported it in 1930, and Rocca and Pereyra later described it in 1963.
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Skin manifestations of diabetes do not get as much attention as other diabetes-related conditions like diabetic foot, diabetic neuropathy and diabetic retinopathy. One reason for this is that diabetic bullae, also called Bullosis diabeticorum is a rare condition affecting only about 0.5% of diabetics in […] The diagnosis of BD entails punch biopsies and subsequent histopathologic examination . The histologic features of bullosis diabeticorum are not very specific. Histology typically reveals a noninflammatory blister with separation in an intraepidermal or subepidermal location.
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The histologic features of bullosis diabeticorum are not very specific. Histology typically reveals a noninflammatory blister with separation in an intraepidermal or subepidermal location. Anchoring fibrils and hemidesmosomes tend to be decreased. The differential diagnosis must be made with epidermolysis bullosa, pemphigus, bullous pemphigoid, burns, erysipelas, arthropod bites and others. The histopathology exam is not typical. The dermatologist should suspect of the disease in long-term diabetic patients of with blisters in acral locations without marked inflammation.
The co-occurrence of neuropathy and nephropathy suggests an underlying microangiopathy. The distribution and appearance of the bulla led to a clinical diagnosis of bullosis diabeticorum, a rare but likely underdiagnosed condition in patients with diabetes. Lesions appear rapidly, primarily in an acral distribution in areas of otherwise normal-appearing skin, and range from a few centimeters to very large. About 0.5% of diabetics develop diabetic bullae or bullosis diabeticorum, a distinct diabetic marker. The bullae occur more frequently in adult men with long standing diabetes and neuropathy.
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More than 24 million Americans have the disease 1, and approximately 11% ($92 billion) of all health care expenditures in the United States were directly attributable to the medical care of diabetes in 2002. 2 Men and women diagnosed with diabetes at age 40 years are expected to lose 12 and 14 life-years Apresenta-se um caso de bullosis diabeticorum, doença rara associada ao diabetes mellitus crônico e complicações como a neuropatia ou nefropatia.
Bullae can appear spontaneously in diabetic patients.
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Monfrecola G, Martellotta D, Bruno G, Delfino M, Iandoli R. The differential diagnosis includes friction bullae, bullae due to burns or edema, bullous fixed drug reaction, bullous pemphigoid, and epidermolysis bullosa acquisita. Bullae resolve spontaneously but can recur, and secondary infection after rupture is a concern.
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1Department of Internal Medicine, Carolinas Medical Center, 1000 Blythe Blvd Suite 507, Charlotte, NC, 28203, USA. Se hela listan på wikem.org We present a case of bullosis diabeticorum. It is a rare disorder, probably underdiagnosed, associated with long-term diabetes mellitus. Its etiology remains unclear.
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Skin manifestations of diabetes do not get as much attention as other diabetes-related conditions like diabetic foot, diabetic neuropathy and diabetic retinopathy. One reason for this is that diabetic bullae, also called Bullosis diabeticorum is a rare condition affecting only about 0.5% of diabetics in […] The diagnosis of BD entails punch biopsies and subsequent histopathologic examination . The histologic features of bullosis diabeticorum are not very specific. Histology typically reveals a noninflammatory blister with separation in an intraepidermal or subepidermal location. Anchoring fibrils and hemidesmosomes tend to be decreased.
e Clinically important is the association of bullosis diabeticorum with diabetic retinopathy, Differential diagnosis. This section has been translated automatically. The diagnosis of BD entails punch biopsies and subsequent histopathologic examination . The histologic features of bullosis diabeticorum are not very specific. Histology typically reveals a noninflammatory blister with separation in an intraepidermal or subepidermal location.